Antibiotic prophylaxis with cefuroxime in arthroplasty of the knee.
نویسنده
چکیده
A randomised prospective trial was undertaken of antibiotic prophylaxis given at various intervals before inflation of the tourniquet for arthroplasty of the knee. Cefuroxime assays of bone and subcutaneous fat from samples collected throughout the operation demonstrated that an interval of 10 minutes was necessary to obtain adequate prophylaxis. Improvement in the timing of antibiotic prophylaxis may result in a reduction in the incidence of infection.
منابع مشابه
Clostridium difficile in patients undergoing primary hip and knee replacement.
Antibiotic prophylaxis is routinely administered during joint replacement surgery and may predispose patients to Clostridium difficile-associated disease (CDAD). The primary aim of this study was to determine the incidence of this following joint replacement, using a cefuroxime-based regimen. Patients developing CDAD were compared with a control group of patients without CDAD. The incidence of ...
متن کاملTiming of antibiotic prophylaxis for primary total knee arthroplasty performed during ischemia.
BACKGROUND There is no clinical trial analyzing the best moment to infuse an antibiotic during knee arthroplasty performed during ischemia. We designed a single-center, randomized, double-blind, placebo-controlled trial to evaluate whether antibiotic therapy should be administered before tourniquet inflation or just before tourniquet deflation. MATERIAL AND METHODS Patients who underwent a pr...
متن کاملEditorial: Antibiotic prophylaxis for hip fracture surgery: three-dose cefuroxime versus single-dose gentamicin and amoxicillin.
in orthopaedic practice. In this issue, Jettoo et al.1 investigated issues related to (1) single versus multiple doses of antibiotic prophylaxis, (2) adverse effects of multiple dosing, and (3) choice of an appropriate antibiotic. In an attempt to address the concomitant problems of cefuroxime-resistant pathogens and Clostridium difficile infections, the authors’ hospital changed the antibiotic...
متن کاملOsteotomy for Revision Total Hip Replacement
Discussion. We previously reported bone and fat levels some I 2 times higher than those after systemic injection (Hoddinott et al 1990) and have now extended our sampling to provide a pharmacokinetic profile over the important 24 hours after operation (Fig. 1). The results indicate that the regional intravenous administration of a single 750 mg dose of cefuroxime gave satisfactory haematoma lev...
متن کاملAntibiotic Prophylaxis and DAIR Treatment in Primary Total Hip and Knee Arthroplasty, A National Survey in The Netherlands
BACKGROUND To prevent postoperative infection the use of systemic antibiotic prophylaxis is common ground. Type of antibiotic used and duration of prophylaxis are subject to debate. In case of suspected early periprosthetic infection a debridement, antibiotics and implant retention (DAIR) procedure is treatment of first choice. This study evaluated the antibiotic prophylaxis and DAIR treatment ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- The Journal of bone and joint surgery. British volume
دوره 69 5 شماره
صفحات -
تاریخ انتشار 1987